Dr. Dhanushka Hewabosthanthige

Senior Lecturer in Anatomy

Department of Anatomy

Faculty of Medicine and Allied Science

Rajarata University of Sri Lanka

Visiting Lecturer - Sabaragamuwa University of Sri Lanka 

• Bachelor of Medicine, Bachelor of Surgery (University of Peradeniya, Sri Lanka)

• MS (Biology - University of Peradeniya, Sri Lanka)

• Doctor of Philosophy (Clark Atlanta University, USA)

• Postdoc fellow - St-Jude Research Children Hospital, USA

• Postdoc fellow - Université de Sherbrooke, Canada

• CRCHUS Postdoctoral Research Fellowship (90K/2 years) - Spring 2023 Edition
• AHEAD grant award for Research 2021 (1.2M SLR)
• UGC Research grant award 2022(0.6M SLR)
• Best Oral presentation National Symposium prostate cancer USA 2017
• 2014 Graduate Scholarship award, Clark Atlanta University
• Awards for appreciation on humanitarian work during civil war to serve people. From Sri Lanka
  Government.
• Undergraduate medical education Scholarship, Faculty of Medicine University of Peradeniya Sri Lanka
  (2000)

7. Hewa Bostanthirige D, Plante C, Sabo Vatasescu JP, Lévesque M, Poirier C, Deschenes M, Chabot B, Laurent B, Geha S and BROSSEAU JP. Proof-of-principle of NF1 Gene Therapy in plexiform neurofibroma mice models. Communications Biology (revision requested)

6. Plante C#, Mohamad T#, Hewa Bostanthirige D#, Renaud M, Sidhu H, ElChoueiry M, Vatasescu JPS, Poirier M, Geha S, Brosseau JP. Revisiting the NPcis mouse model: a new tool to model plexiform neurofibroma. PLoS ONE. 2024.

5. Jablonowski CM, Quarni W, Singh S, Tan H, Hewa Bostanthirige D, Jin H, Fang J, Chang TC, Finkelstein D, Cho JH, Hu D, Pagala V, Sakurada SM, Pruett-Miller SM, Wang R, Murphy A, Freeman K, Peng J, Davidoff AM, Wu G, Yang J. Metabolic reprogramming of cancer cells by JMJD6-mediated pre-mRNA splicing associated with a therapeutic response to splicing inhibitor. Elife. 2024 Mar 15;12:RP90993 PMID :38488852

4. Rhéaume K#, Chen Z#, Wang Y#, Plante C, Hewa Bostanthirige D, Lévesque M, Geha S, Le LQ and Brosseau JP. Whole central and      peripheral nervous system mice dissection. Journal of Visualized Experiments. 2023 (192), e64974. PMID: 36912549.

3. Hewa Bostanthirige D, Komaragiri SK, Joshi JB, Alzahrani M, Saini I, Jain S, Bowen NJ, Havrda MC, Chaudhary. The helix-loop-helix transcriptional regulator Id4 is required for terminal differentiation of luminal epithelial cells in the prostate. Journal of Oncoscience. 2021 Mar 24;8:14-30. PMID :33884281

2. Joshi JB, Patel D, Morton DJ, Sharma P, Zou J, Hewa Bostanthirige D, Gorantla Y, Nagappan P, Komaragiri SK, Sivils JC, Xie H, Palaniappan R, Wang G, Cox MB, Chaudhary J. Inactivation of ID4 promotes a CRPC phenotype with constitutive AR activation through FKBP52. Mol Oncol. 2017 Apr;11(4):337-357 PMID :28252832

1.Komaragiri SK, Hewa Bostanthirige D, Morton DJ, Patel D, Joshi J, Upadhyay S, Chaudhary J. ID4 promotes AR expression and blocks tumorigenicity of PC3 prostate cancer cells. Biochem Biophys Res Commun. 2016 Sep 9;478(1):60-66. PMID :27462022